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We work together mt-pharma-us.com Improvised explosive devices (IEDs) are the single biggest killer in the Afghan conflict, according to a U.N. report that recorded a 53 percent increase in victims -- mostly children --last year. IEDs caused over a third of civilian casualties in the first six months of 2013, during which over 1,300 were killed and 2,500 wounded -- 23 percent more than the same period last year.